Segregação mitótica induzida pelo edulcorante L-Aspartil-L-Fenilalanina-Metil-Ester (aspartame) em células diplóides de Aspergillus nidulans - DOI: 10.4025/actascibiolsci.v25i1.2121

Josil Santos Gebara; Carmem Boto Querol; Munif Gebara; Marialba Avezum Alves Castro Prado

doi:10.4025/actascibiolsci.v25i1.2121

Mitotic segregation induced by edulcorant l-aspartyl-l-phenylalanine-metyl-ester (aspartame) in diploid cells of Aspergillus nidulans - DOI: 10.4025/actascibiolsci.v25i1.2121

Authors

Josil Santos Gebara UEM Author
Carmem Boto Querol UEM Author
Munif Gebara UEM Author
Marialba Avezum Alves Castro Prado UEM Author

DOI:

https://doi.org/10.4025/actascibiolsci.v25i1.2121

Keywords:

carcinogênese, edulcorantes, recombinogênese, perda de heterozigose

Abstract

This study aims to verify the recombinogenic effect of artificial edulcorant l-aspartil-l-phenylalanine-metyl-ester (aspartame), widely used in hypocaloric and low-glucose diets. Such effect may reflect cell response to genetic damage, induced by artificial edulcorant in the cell cycle G2 period and shows its capacity to induce homozygosis of recessive genes, previously present in heterozygosis

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Author Biography

Marialba Avezum Alves Castro Prado, UEM

possui graduação em Bacharelado Em Ciências Biológicas pela Organização Educacional Barão de Mauá (1980), mestrado em Ciências Biológicas (Genética) pela Universidade de São Paulo (1985) e doutorado em Ciências Biológicas (Genética) pela Universidade de São Paulo (1992). Atualmente é professor associado - nível c da Universidade Estadual de Maringá. Tem experiência na área de Genética, com ênfase em Controle da Expressão Gênica, atuando principalmente nos seguintes temas: Parassexualidade em fungos filamentosos, Genética do desenvolvimento, Controle do crossing-over e Genotoxicidade (recombinação mitótica) de substâncias químicas Currículo Lattes

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PDF (Portuguese)

Published

2008-04-18

Issue

Vol. 25 No. 1 (2003)

Section

Biology Sciences

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How to Cite

Mitotic segregation induced by edulcorant l-aspartyl-l-phenylalanine-metyl-ester (aspartame) in diploid cells of Aspergillus nidulans - DOI: 10.4025/actascibiolsci.v25i1.2121. (2008). Acta Scientiarum. Biological Sciences, 25(1), 203-206. https://doi.org/10.4025/actascibiolsci.v25i1.2121