IDENTIFICATION OF CRITICAL LACTATION STAGE FOR THE BODY COMPOSITION IN MALE OFFSPRING OF HIGH-FAT FED DAMS

  • Maryana Debossan Fernandes
  • Ananda Malta
  • Letícia Ferreira Barbosa
  • Scarlett Rodrigues Raposo
  • Marcos Vinícius Martins
  • Gabriel Kian Guimarães Lopes
  • Douglas Lopes Almeida
  • Paulo Cezar de Freitas Mathias

Resumo

Each stage (early, middle and late) of lactation is a critical period during which maternal
malnutritional can negatively effects on the offspring's body development. We investigated
the effects of a maternal high fat diet (HF) during the different stages of lactation on body
weight of male offspring at weaning. Female Wistar rats were fed either a HF diet only during
the first week (HF1-7 group), second week (HF7-14 group), third week (HF14-21 group) and
throughout lactation (group HF1-21) or standard diet during all lactation. Biometric
parameters of dams and male offspring were evaluated. HF fed dams did not have a difference
in body weight, food intake and fat pad compared with the control dams. Regarding the
offspring, a higher final body weight was observed in males from the HF7-14 and HF14-21
and HF21 groups compared to the control. There was an increase in retroperitoneal and
mesenteric fat in HF21 and HF14-21 compared with control groups. Higher perigonadal fat
pat was only observed in HF21. Consumption of maternal HF diet throughout lactation causes
high body weight in male offspring. Interestingly, each isolated phase also causes important
body weight accumulation, mainly the second and third week.

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Referências

1st International Symposium of DOHaD & Pandemic: Lessons from COVID-19
Publicado
2023-05-10
Como Citar
1.
Debossan Fernandes M, Malta A, Ferreira Barbosa L, Rodrigues Raposo S, Vinícius Martins M, Kian Guimarães Lopes G, Lopes Almeida D, Cezar de Freitas Mathias P. IDENTIFICATION OF CRITICAL LACTATION STAGE FOR THE BODY COMPOSITION IN MALE OFFSPRING OF HIGH-FAT FED DAMS. arqmudi [Internet]. 10º de maio de 2023 [citado 6º de setembro de 2025];27(ESPECIAL1). Disponível em: https://periodicos.uem.br/ojs/index.php/ArqMudi/article/view/68178
Seção
2. Early life programming of non-communicable diseases: metabolic and epigenetic