MATERNAL RESTRICTIVE DIETS DURING LACTATION IMPAIR GABAERGIC SIGNALING IN THE HYPOTHALAMUS AND MIDBRAIN IN MALE ADULT RATS

  • Isadora S. Rosa
  • Keilah V. N. Cavalcante
  • Marcos D. F. Junior
  • Juliana V. V. Ribeiro
  • Ariel P. C. Mota
  • Maria E. R. Silva
  • Jose A. B. L. Sobrinho
  • Carlos H. Xavier
  • Gustavo R. Pedrino
  • Rodrigo Mello Gomes

Resumo

The aim of this work was to evaluate the behavioral parameters and the GABAergic signaling
in the hypothalamus, midbrain and medulla. Mothers and litters were distributed into 3
groups: Control (CO) fed with standard diet (20% protein), food restriction (FR) with
standard diet limited of 50% of the daily consumption of CO, and low-protein (LP) fed with
LP-diet (4% protein). Interventions were carried out from the 1st-14th, and 14 th -21st day of
lactation. Offspring of both sexes were evaluated until 120 days old by elevated plus maze
(EPM) and open field (OP) test. Male LP rats showed a decrease in the closed arm (CO
158±11.51 vs LP 105.5±9.63; s), an increase in the open arm (CO 85.10±8.65 vs LP
139.8±12.36; s) time, and in the number of open arm entries (CO 5.25±0.58 vs LP 8.40±0.79;
a.u.) compared to the CO. In OP, male LP rats showed an increase in crossings (CO
51.94±4.29 vs LP 71±3.41; a.u.) and in the frequency of crossings (CO 51.94±4.29 vs
69.25±4.44; a.u.) compared to the CO. Male FR showed a decrease in the expression of
GABA B receptors (CO 100±12.60 vs FR 56.34 v 4.19; % control). In the midbrain, male LP
and FR showed a decrease in GAD (CO 100±11.22 vs LP 47.59±6.21 vs FR 74.18±8.82; %
control) compared to the CO. In conclusion, maternal protein and caloric restriction during
lactation induces less anxious behavior and increases exploratory activity in males in
adulthood, through modulation in GABAergic signaling.

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Referências

1st International Symposium of DOHaD & Pandemic: Lessons from COVID-19
Publicado
2023-05-10
Como Citar
1.
S. Rosa I, V. N. Cavalcante K, D. F. Junior M, V. V. Ribeiro J, P. C. Mota A, E. R. Silva M, A. B. L. Sobrinho J, H. Xavier C, R. Pedrino G, Mello Gomes R. MATERNAL RESTRICTIVE DIETS DURING LACTATION IMPAIR GABAERGIC SIGNALING IN THE HYPOTHALAMUS AND MIDBRAIN IN MALE ADULT RATS. arqmudi [Internet]. 10º de maio de 2023 [citado 6º de setembro de 2025];27(ESPECIAL1). Disponível em: https://periodicos.uem.br/ojs/index.php/ArqMudi/article/view/68188
Seção
3. Environmental and dietary influences on the onset of noncommunicable diseases