NICOTINE EXPOSURE DURING BREASTFEEDING ALTERS CARDIAC PARAMETERS IN MALE AND FEMALE OFFSPRING

Carla  Carolina Rodrigues da Silveira; Marcos  Divino Ferreira-Junior; Keilah  Valéria Naves Cavalcante; Ariel  Penha Carvalho da Mota; Patrícia  Cristina Lisbôa da Silva; Rodrigo  Mello Gomes

doi:10.4025/arqmudi.v27iESPECIAL.68201

NICOTINE EXPOSURE DURING BREASTFEEDING ALTERS CARDIAC PARAMETERS IN MALE AND FEMALE OFFSPRING

Carla Carolina Rodrigues da Silveira
Marcos Divino Ferreira-Junior
Keilah Valéria Naves Cavalcante
Ariel Penha Carvalho da Mota
Patrícia Cristina Lisbôa da Silva
Rodrigo Mello Gomes

DOI: https://doi.org/10.4025/arqmudi.v27iESPECIAL.68201

Keywords: DOHaD, Lactation, Cardiac Hypertrophy

Abstract

Nicotine is one of the main psychoactive and toxic substances found in tobacco and its
exposure during the postnatal period can cause several damages to the health of the child
during intrauterine development and in adult life. The aim of this study was to evaluate the
effect of maternal postnatal nicotine exposure on cardiac parameters in adult rat offspring.
Weight monitoring, echocardiography and organ collections were performed. In conclusion,
offspring from mothers exposed to nicotine develops cardiac hypertrophy, further male
offspring were more affected.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

1. WHO. Strategy and Plan of Action to Strengthen Tobacco Control in the Region of the
Americas. 2019b. Disponível em: https://escholarship.org/uc/item/0cv1s712 . Acesso em
17 fev. 2021.
2. WHO. Summary results of the global youth tobacco survey in selected countries of the
WHO European Region. 2020b. Disponível em:
https://escholarship.org/uc/item/6nd8n6vh . Acesso em 17 fev. 2021.
3. WHO. Tobacco & Coronary Heart Disease. 2020a. Disponível em:
https://escholarship.org/uc/item/2ht8d53v . Acesso em 17 fev. 2021.
4. WHO. WHO report on the global tobacco epidemic 2019: offer help to quit tobacco use.
2019a. Disponível em: https://escholarship.org/uc/item/1g16k8b9 . Acesso em 17 fev.
2021.

5. GIBBS K.; COLLACO, J. M.; MCGRATH-MORROW, S. A. Impact of Tobacco Smoke
and Nicotine Exposure on Lung Development. Chest, v. 149, n. 2, 552- 561, fev. 2016.
6. HANNÖVER, W. et al. Smoking During Pregnancy and Postpartum: smoking rates and
intention to quit smoking or resume after pregnancy. Journal Of Women’S Health, v. 17,
n. 4, p. 631-640, maio 2008
7. OLIVEIRA, E.; PINHEIRO, C. R.; SANTOS-SILVA, A. P.; TREVENZOLI, I. H.;
ABREU-VILLAÇA, Y.; NOGUEIRA NETO, J. F.; REIS, A. M.; PASSOS, M. C.;
MOURA, E. G.; LISBOA, P. C. Nicotine exposure affects mother's and pup’s nutritional,
biochemical, and hormonal profiles during lactation in rats. Journal of Endocrinology, v.
205, n. 2, p. 159-170, maio 2010.
8. SINHA-HIKIM, I. et al. Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis.
Cell and Tissue Research, v. 368, p. 159-170, 2016.
9. MOON, H. K. Effects of 1,8-cineole on hypertension induced by chronic exposure to
nicotine in rats. Journal of Pharmacy and Pharmacology, v. 66, p. 688-693, 2014.
10. COOKE, W. H. et al. Acute inhalation of vaporized nicotine increases arterial pressurein
young non-smokers: a pilot study. Clinical Autonomic Research, v. 25, p. 267-270, 2015.
11. YAGI, S. T. M.; SATOMIA, J. Possible role of afferent autonomic signals in abdominal
organs in anorexic and cardiovascular responses to nicotine injection in rats.
NeuroReport, v. 26, n. 8, 2015.
12. RODRIGUES, V.S.T.; et al. Neonatal nicotine exposure changes insulin status in fat
depots: sex-related differences. Journal of Developmental Origins of Health and Disease,
v. 13, p.252 – 262, 2022.
13. DONNY, E.C.; et ali. Self-administered and yoked nicotine produce robust increases in
blood pressure and changes in heart rate with modest effects of behavioral contingency in
rats. Pharmacology, Biochemistry and Behavior, v. 99, p. 459 – 467, 2011.
14. CHOU, H. C.; CHEN, H. C. Maternal nicotine exposure during gestation and lactation
induces cardiac remodeling in rat offspring. Reproductive Toxicology, v.80, p. 4-10,
2014.

pdf
html

Published

2023-05-10

How to Cite

Carolina Rodrigues da Silveira C, Divino Ferreira-Junior M, Valéria Naves Cavalcante K, Penha Carvalho da Mota A, Cristina Lisbôa da Silva P, Mello Gomes R. NICOTINE EXPOSURE DURING BREASTFEEDING ALTERS CARDIAC PARAMETERS IN MALE AND FEMALE OFFSPRING. arqmudi [Internet]. 2023May10 [cited 2025Sep.6];27(ESPECIAL1). Available from: https://periodicos.uem.br/ojs/index.php/ArqMudi/article/view/68201

Download Citation

Issue

Vol 27 No ESPECIAL1 (2023): 1st International Symposium of DOHaD & Pandemic: Lessons from COVID-19

Section

3. Environmental and dietary influences on the onset of noncommunicable diseases

DECLARAÇÃO DE ORIGINALIDADE E DIREITOS AUTORAIS

Declaro que o presente artigo é original, não tendo sido submetido à publicação em qualquer outro periódico nacional ou internacional, quer seja em parte ou em sua totalidade.

Os direitos autorais pertencem exclusivamente aos autores. Os direitos de licenciamento utilizados pelo periódico é a licença Creative Commons Attribution 4.0 (CC BY ): são permitidos o acompartilhamento (cópia e distribuição do material em qualqer meio ou formato) e adaptação (remix, transformação e criação de material a partir do conteúdo assim licenciado para quaisquer fins, inclusive comerciais.

Recomenda-se a leitura desse link para maiores informações sobre o tema: fornecimento de créditos e referências de forma correta, entre outros detalhes cruciais para uso adequado do material licenciado.