MATERNAL FOOD RESTRICTION DURING LACTATION LEADS TO SEX-SPECIFIC BLOOD HYPERTENSION AND CARDIAC REMODELING IN THE OFFSPRING
Resumen
Dietary restriction during pregnancy and puberty is a risk factor to hypertension onset at
adulthood. The aim of this study was to evaluate the effect of maternal malnutrition during
lactation on cardiovascular parameters, in both sexes of rat pups at 120-day-old. Maternal
food restriction lead to arterial hypertension, baroreflex impairment, cardiac remodeling and
increased collagen deposition in the aorta, in adult male offspring. The females did not show
functional or morphological disruptions. Together, these results show that maternal food
restriction during lactation promotes cardiometabolic programming, generating cardiovascular
alterations in male adult rat offspring, however female offspring present some kind of
cardioprotective effect.
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