Vitamin D deficiency and cardiovascular mortality in chronic kidney disease: integrative review
DOI:
https://doi.org/10.4025/ciencuidsaude.v20i0.50127Keywords:
Vitamin D deficiency, Mortality, Chronic Kidney DiseaseAbstract
Objective: To analyze scientific studies that have addressed vitamin D deficiency and cardiovascular mortality in people with chronic kidney disease. Method: This is an integrative literature review conducted through the LILACS, PubMed and Medline databases, and through the SciELO electronic library, using the ‘vitamin D deficiency’, ‘cardiovascular mortality’ and ‘chronic kidney disease’ descriptors, with 14 articles being selected for analysis. Results: By analyzing the selected articles, it was possible to identify that vitamin D deficiency and cardiovascular mortality are very common conditions in chronic renal patients and, for this reason, there are hypotheses that correcting this deficiency may have beneficial effects on the disease and cardiovascular mortality in this population. Conclusion: There is an intrinsic relationship between vitamin D deficiency and cardiovascular mortality. However, it is still debatable whether vitamin D supplementation reduces cardiovascular mortality in chronic renal patients. Such hypothesis needs to be tested in clinical trials, which gives cause for the need to develop further research on the theme.
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2. Bastos MG, Kirsztajn GM. Chronickidneydisease: importanceofearlydiagnosis, immediatereferralandstructuredinterdisciplinary approach to improve outcomes in patientsnotyetondialysis. JBrasNefrol. 2011; 13(4): 93-108. Doi: http://dx.doi.org/10.1590/S010128002011000100013
3. Pereira ERS, Pereira ADC, Andrade GB, Naghenetti AV, Pinto FKMS, Batista SR, et al. Prevalenceofchronic renal disease in adultsattendedbythe Family healthstrategy. J BrasNefrol. 2016; 38(1): 22-30. Doi: http://dx.doi.org/10.5935/0101-2800.20160005
4. Alani H, Tamimi A, Tamimi N. Cardiovascular co-morbidity in chronic kidney disease: Current knowledge and future research needs.World J Nephrol. 2014; 13(3):156-168. Doi:10.5527 / wjn.v3.i4.156
5. Monteiro Junior FDC, Mandarino, NR, Salgado, JVL, Lages JS, Filho NS. Deficiência de Vitamina D: um Novo Fator de Risco Cardiovascular?.RevBrasCardiol. 2014; 12(2): 356-365. Disponível em: http://www.rbconline.org.br/artigo/deficiencia-de-vitamina-d-um-novo-fator-de-risco-cardiovascular/
6. Zheng Z, Shi H, Jia J, Li D, Lin S. Vitamin D supplementation and mortality risk in chronic kidney disease: a meta-analysis of 20 observational studies. BMC Nephrol. 2013; 14(3): 1-13. Doi: 10.1186/1471-2369-14-199
7. Cozzolino M, Covic A, Placencia BM, Konstantinos X. Treatment failure of active vitamin D therapy in chronic kidney disease: Predictive factors. Am J Nephrol. 2015; 42(3):228–236. Doi:https://doi.org/10.1159/000441095
8. Mendes KDS, Silveira RCCP, Galvão CM. Use ofthebibliographicreference manager in theselectionofprimarystudies in integrativereviews. Texto contexto - enferm. [Internet]. 2019 [cited 2020 July 20] ; 28: e20170204. Doi: http://dx.doi.org/10.1590/1980-265x-tce-2017-0204
9. Melnyk BM, Finout-Overholt E. Evidence-based practice in nursing & healthcare: a guide to best practice. CritCare Nurse. 2014;34(3):174- 178.
10. Polit DF, Beck CT. Fundamentos de pesquisa em enfermagem: avaliação de Evidências para a Prática da Enfermagem. 9a ed. Porto Alegre (RS): Artmed;2018.
11. Duranton F, Ortiz MER, Duny Y, Rodriguez M, Daurès P, Argilés A. Vitamin D Treatment and Mortality in Chronic Kidney Disease: A Systematic Review and Meta-Analysis. Am J Nephrol. 2013;239–248. Doi: http://dx.doi.org/10.1159/000346846
12. Filho AJI, Melamed ML. Vitamin D andKidneyDisease. Whatweknowandwhatwe do notknowJ BrasNefrol. 2013;323-331. Doi: http://dx.doi.org/10.5935/0101-2800.20130051
13. Mann MC, Hoobs AJ, Hemmelgarn BR, Roberts DJ, Ahmed SB, Rabi DM. Effect of oral vitamin D analogs on mortality and cardiovascular outcomes among adults with chronic kidney disease: a meta-analysis. ClinKidney J. 2014;41–48. Doi: http://dx.doi.org/10.1093/ckj/sfu122
14. Parikh C, Gutgarts V, Eisenberg E, Melamed ML. Vitamin D and Clinical Outcomes in Dialysis. Semin Dial. 2014; 28(6):604–609. Doi:http://dx.doi.org/10.1111/sdi.12446
15. Ferreira A, Aires I, Nolasco F, Machado D, Macário F, Neves PL, et al. Benefits of selective vitamin D receptor activators in kidney transplanted patients. Port J NephrolHypert. 2015; 29(3):194-206. Disponível em: http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S087201692015000300003&lng=en.
16. Sekercioglu N, Busse JW, Sekercioglu MF, Agarwal A, Shaikh S, Lopes LC, et al. Cinacalcet versus standard treatment for chronic kidney disease: a systematic review and metaanalysis. RenFail. 2016; 38(6):857–874. Doi: http://dx.doi.org/10.3109/ 0886022X.2016.1172468
17. Magalhães LP, Reis LMD, Graciolli FG, Pereira BJ, Oliveira RBD, Souza AALD, et al. Predictive Factors of One-Year Mortality in a Cohort of Patients Undergoing Urgent-Start Hemodialysis. PloSOne. 2017; 1(3):1-8. Disponível em: https://observatorio.fm.usp.br/handle/OPI/18996
18. Hou YC, Liu WC, Zheng CM, Yen TH, Lu KC. Role of Vitamin D in Uremic Vascular Calcification. BioMedRes.Int. 2017; 1-11. DOI: https://doi.org/10.1155/2017/2803579
19. Shardlow A, Mclntyre NJ, Fluck RJ, Mclntyre CW, Taal MW. Associations of fibroblast growth factor 23, vitamin D and parathyroid hormone with 5 year outcomes in a prospective primary care cohort of people with chronic kidney disease stage 3. BMJ Open. 2017; 28(4): 83-92. Doi: http://dx.doi.org/10.1136/bmjopen-2017-016528
20. Hamano T. Vitamin D and renal outcome: the fourth outcome of CKD-MBD? Oshima AwardAddress 2015. J ClinExpNephrol .2018; 22(3): 249-256. Doi: http://dx.doi.org/10.1007/s10157-017-1517-3
21. Brzozka AG, Franzyck B, Ryzs AC, Olszewski R, Ryzs J. Impact of Vitamin D on the Cardiovascular System in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients. Nutrients. 2018;10(4):709-718. Doi:http://dx.doi.org/10.3390/nu10060709
22. Chen X, Lu YP, Luo T, Wu HW, Cai SF, Tian M, et al. Free 25-Vitamin D Is Correlated with Cardiovascular Events in Prevalent Hemodialysis Patients but Not with Markers of Renal Mineral Bone Disease. KidneyBlood Press Res. 2019;44(2):344-353.Doi:http://dx.doi.org/10.1159/000499878
23. Junarta J, Vivekanad JHA, Banerjee D. Insight into the impact of vitamin D on cardiovascular outcomes in chronic kidney disease. Nephrology. 2019; 24:781-90. Doi:https://doi.org/10.1111/nep.13569
24. Jean G, Souberbielle JC, Chazot C. Vitamin D in Chronic Kidney Disease and Dialysis Patients. Nutrients. 2017; 9(4) Doi:https://doi.org/10.3390/nu9040328
25. Kidney Disease: Improving Global Outcomes (KDIGO). KDIGO clinical practice guidelines for the diagnosis, evaluation, prevention and treatment of chronic kidney diseasemineral and bone disorder (CKD-MBD). KidneyIntSuppl. 2017;7:1-59
26. Matsumoto AK, Maes M, Michelin AP, Soares AE, Semeão LO, Godeny P, et al. Vitamin D deficiency is not associated with increased oxidative stress in chronic kidney disease pre-dialysis patients. Braz J Nephrol. 2020;42(4):420-8 Doi: https://doi.org/10.1590/2175-8239-jbn-2019-0156
27. Liu WC, Zheng CM, Lu CL et al: Vitamin D and immune function in chronic kidney disease. ClinChim Acta. 2015; 450:135-44. Doi: https://doi.org/10.1016/j.cca.2015.08.011
28. Jorge AJL, Cordeiro JR, Rosa MLG, Bianchi DBC. Deficiência da Vitamina D e Doenças Cardiovasculares Int J Cardiovasc Sci.2018; [online].aheadprint, PP.0-0 Doi:https://doi.org/10.5935/2359-4802.20180025








