Deficiencia de vitamina D y mortalidad cardiovascular en la enfermedad renal crónica: revisión integradora
DOI:
https://doi.org/10.4025/ciencuidsaude.v20i0.50127Palabras clave:
Deficiencia de vitamina D, Mortalidad, Insuficiencia Renal CrónicaResumen
Objetivo: analizar los estudios científicos desarrollados sobre la deficiencia de vitamina D yla mortalidad por causa cardiovascular en las personas conenfermedad renal crónica. Método: se trata de una revisión integradora de la literatura a partir de las bases de datos LILACS, PubMed, Medline yen la biblioteca electrónica SciELO, utilizando los descriptores deficiencia de vitamina D; mortalidad cardiovascular yenfermedad renal crónica, siendo seleccionados 14 artículos para el análisis. Resultados: a partir del análisis de los artículos seleccionados, fue posible identificar que la deficiencia de vitamina D yla mortalidad cardiovascular son condiciones muy frecuentes en enfermos renales crónicos y, por ello, se discuten hipótesis de que la corrección de esta deficiencia puede ejercer efectos benéficos sobre la enfermedady mortalidad cardiovascular enesta población. Conclusión: hay una intrínseca relación entre la carencia de vitamina D yla mortalidad cardiovascular. Sin embargo, aúnes discutible sila suplementación de vitamina D reducela mortalidad cardiovascular en los enfermos renales crónicos. Tal hipótesisnecesita ser probada en ensayos clínicos, fomentando la necesidad de desarrollarse más investigaciones sobre el tema.
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Referencias
1. Malta DC, Bernal RTI, Lima MG, Araujo SSCD, Silva MMAD, Freitas MIDF et al. Noncommunicablediseasesandthe use ofhealthservices: analysisoftheNational Health Survey in Brazil. RevSaude Publica. 2017; 51(Suppl 1): 4s. Doi: http://dx.doi.org/10.1590/s1518-8787.2017051000090
2. Bastos MG, Kirsztajn GM. Chronickidneydisease: importanceofearlydiagnosis, immediatereferralandstructuredinterdisciplinary approach to improve outcomes in patientsnotyetondialysis. JBrasNefrol. 2011; 13(4): 93-108. Doi: http://dx.doi.org/10.1590/S010128002011000100013
3. Pereira ERS, Pereira ADC, Andrade GB, Naghenetti AV, Pinto FKMS, Batista SR, et al. Prevalenceofchronic renal disease in adultsattendedbythe Family healthstrategy. J BrasNefrol. 2016; 38(1): 22-30. Doi: http://dx.doi.org/10.5935/0101-2800.20160005
4. Alani H, Tamimi A, Tamimi N. Cardiovascular co-morbidity in chronic kidney disease: Current knowledge and future research needs.World J Nephrol. 2014; 13(3):156-168. Doi:10.5527 / wjn.v3.i4.156
5. Monteiro Junior FDC, Mandarino, NR, Salgado, JVL, Lages JS, Filho NS. Deficiência de Vitamina D: um Novo Fator de Risco Cardiovascular?.RevBrasCardiol. 2014; 12(2): 356-365. Disponível em: http://www.rbconline.org.br/artigo/deficiencia-de-vitamina-d-um-novo-fator-de-risco-cardiovascular/
6. Zheng Z, Shi H, Jia J, Li D, Lin S. Vitamin D supplementation and mortality risk in chronic kidney disease: a meta-analysis of 20 observational studies. BMC Nephrol. 2013; 14(3): 1-13. Doi: 10.1186/1471-2369-14-199
7. Cozzolino M, Covic A, Placencia BM, Konstantinos X. Treatment failure of active vitamin D therapy in chronic kidney disease: Predictive factors. Am J Nephrol. 2015; 42(3):228–236. Doi:https://doi.org/10.1159/000441095
8. Mendes KDS, Silveira RCCP, Galvão CM. Use ofthebibliographicreference manager in theselectionofprimarystudies in integrativereviews. Texto contexto - enferm. [Internet]. 2019 [cited 2020 July 20] ; 28: e20170204. Doi: http://dx.doi.org/10.1590/1980-265x-tce-2017-0204
9. Melnyk BM, Finout-Overholt E. Evidence-based practice in nursing & healthcare: a guide to best practice. CritCare Nurse. 2014;34(3):174- 178.
10. Polit DF, Beck CT. Fundamentos de pesquisa em enfermagem: avaliação de Evidências para a Prática da Enfermagem. 9a ed. Porto Alegre (RS): Artmed;2018.
11. Duranton F, Ortiz MER, Duny Y, Rodriguez M, Daurès P, Argilés A. Vitamin D Treatment and Mortality in Chronic Kidney Disease: A Systematic Review and Meta-Analysis. Am J Nephrol. 2013;239–248. Doi: http://dx.doi.org/10.1159/000346846
12. Filho AJI, Melamed ML. Vitamin D andKidneyDisease. Whatweknowandwhatwe do notknowJ BrasNefrol. 2013;323-331. Doi: http://dx.doi.org/10.5935/0101-2800.20130051
13. Mann MC, Hoobs AJ, Hemmelgarn BR, Roberts DJ, Ahmed SB, Rabi DM. Effect of oral vitamin D analogs on mortality and cardiovascular outcomes among adults with chronic kidney disease: a meta-analysis. ClinKidney J. 2014;41–48. Doi: http://dx.doi.org/10.1093/ckj/sfu122
14. Parikh C, Gutgarts V, Eisenberg E, Melamed ML. Vitamin D and Clinical Outcomes in Dialysis. Semin Dial. 2014; 28(6):604–609. Doi:http://dx.doi.org/10.1111/sdi.12446
15. Ferreira A, Aires I, Nolasco F, Machado D, Macário F, Neves PL, et al. Benefits of selective vitamin D receptor activators in kidney transplanted patients. Port J NephrolHypert. 2015; 29(3):194-206. Disponível em: http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S087201692015000300003&lng=en.
16. Sekercioglu N, Busse JW, Sekercioglu MF, Agarwal A, Shaikh S, Lopes LC, et al. Cinacalcet versus standard treatment for chronic kidney disease: a systematic review and metaanalysis. RenFail. 2016; 38(6):857–874. Doi: http://dx.doi.org/10.3109/ 0886022X.2016.1172468
17. Magalhães LP, Reis LMD, Graciolli FG, Pereira BJ, Oliveira RBD, Souza AALD, et al. Predictive Factors of One-Year Mortality in a Cohort of Patients Undergoing Urgent-Start Hemodialysis. PloSOne. 2017; 1(3):1-8. Disponível em: https://observatorio.fm.usp.br/handle/OPI/18996
18. Hou YC, Liu WC, Zheng CM, Yen TH, Lu KC. Role of Vitamin D in Uremic Vascular Calcification. BioMedRes.Int. 2017; 1-11. DOI: https://doi.org/10.1155/2017/2803579
19. Shardlow A, Mclntyre NJ, Fluck RJ, Mclntyre CW, Taal MW. Associations of fibroblast growth factor 23, vitamin D and parathyroid hormone with 5 year outcomes in a prospective primary care cohort of people with chronic kidney disease stage 3. BMJ Open. 2017; 28(4): 83-92. Doi: http://dx.doi.org/10.1136/bmjopen-2017-016528
20. Hamano T. Vitamin D and renal outcome: the fourth outcome of CKD-MBD? Oshima AwardAddress 2015. J ClinExpNephrol .2018; 22(3): 249-256. Doi: http://dx.doi.org/10.1007/s10157-017-1517-3
21. Brzozka AG, Franzyck B, Ryzs AC, Olszewski R, Ryzs J. Impact of Vitamin D on the Cardiovascular System in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients. Nutrients. 2018;10(4):709-718. Doi:http://dx.doi.org/10.3390/nu10060709
22. Chen X, Lu YP, Luo T, Wu HW, Cai SF, Tian M, et al. Free 25-Vitamin D Is Correlated with Cardiovascular Events in Prevalent Hemodialysis Patients but Not with Markers of Renal Mineral Bone Disease. KidneyBlood Press Res. 2019;44(2):344-353.Doi:http://dx.doi.org/10.1159/000499878
23. Junarta J, Vivekanad JHA, Banerjee D. Insight into the impact of vitamin D on cardiovascular outcomes in chronic kidney disease. Nephrology. 2019; 24:781-90. Doi:https://doi.org/10.1111/nep.13569
24. Jean G, Souberbielle JC, Chazot C. Vitamin D in Chronic Kidney Disease and Dialysis Patients. Nutrients. 2017; 9(4) Doi:https://doi.org/10.3390/nu9040328
25. Kidney Disease: Improving Global Outcomes (KDIGO). KDIGO clinical practice guidelines for the diagnosis, evaluation, prevention and treatment of chronic kidney diseasemineral and bone disorder (CKD-MBD). KidneyIntSuppl. 2017;7:1-59
26. Matsumoto AK, Maes M, Michelin AP, Soares AE, Semeão LO, Godeny P, et al. Vitamin D deficiency is not associated with increased oxidative stress in chronic kidney disease pre-dialysis patients. Braz J Nephrol. 2020;42(4):420-8 Doi: https://doi.org/10.1590/2175-8239-jbn-2019-0156
27. Liu WC, Zheng CM, Lu CL et al: Vitamin D and immune function in chronic kidney disease. ClinChim Acta. 2015; 450:135-44. Doi: https://doi.org/10.1016/j.cca.2015.08.011
28. Jorge AJL, Cordeiro JR, Rosa MLG, Bianchi DBC. Deficiência da Vitamina D e Doenças Cardiovasculares Int J Cardiovasc Sci.2018; [online].aheadprint, PP.0-0 Doi:https://doi.org/10.5935/2359-4802.20180025
2. Bastos MG, Kirsztajn GM. Chronickidneydisease: importanceofearlydiagnosis, immediatereferralandstructuredinterdisciplinary approach to improve outcomes in patientsnotyetondialysis. JBrasNefrol. 2011; 13(4): 93-108. Doi: http://dx.doi.org/10.1590/S010128002011000100013
3. Pereira ERS, Pereira ADC, Andrade GB, Naghenetti AV, Pinto FKMS, Batista SR, et al. Prevalenceofchronic renal disease in adultsattendedbythe Family healthstrategy. J BrasNefrol. 2016; 38(1): 22-30. Doi: http://dx.doi.org/10.5935/0101-2800.20160005
4. Alani H, Tamimi A, Tamimi N. Cardiovascular co-morbidity in chronic kidney disease: Current knowledge and future research needs.World J Nephrol. 2014; 13(3):156-168. Doi:10.5527 / wjn.v3.i4.156
5. Monteiro Junior FDC, Mandarino, NR, Salgado, JVL, Lages JS, Filho NS. Deficiência de Vitamina D: um Novo Fator de Risco Cardiovascular?.RevBrasCardiol. 2014; 12(2): 356-365. Disponível em: http://www.rbconline.org.br/artigo/deficiencia-de-vitamina-d-um-novo-fator-de-risco-cardiovascular/
6. Zheng Z, Shi H, Jia J, Li D, Lin S. Vitamin D supplementation and mortality risk in chronic kidney disease: a meta-analysis of 20 observational studies. BMC Nephrol. 2013; 14(3): 1-13. Doi: 10.1186/1471-2369-14-199
7. Cozzolino M, Covic A, Placencia BM, Konstantinos X. Treatment failure of active vitamin D therapy in chronic kidney disease: Predictive factors. Am J Nephrol. 2015; 42(3):228–236. Doi:https://doi.org/10.1159/000441095
8. Mendes KDS, Silveira RCCP, Galvão CM. Use ofthebibliographicreference manager in theselectionofprimarystudies in integrativereviews. Texto contexto - enferm. [Internet]. 2019 [cited 2020 July 20] ; 28: e20170204. Doi: http://dx.doi.org/10.1590/1980-265x-tce-2017-0204
9. Melnyk BM, Finout-Overholt E. Evidence-based practice in nursing & healthcare: a guide to best practice. CritCare Nurse. 2014;34(3):174- 178.
10. Polit DF, Beck CT. Fundamentos de pesquisa em enfermagem: avaliação de Evidências para a Prática da Enfermagem. 9a ed. Porto Alegre (RS): Artmed;2018.
11. Duranton F, Ortiz MER, Duny Y, Rodriguez M, Daurès P, Argilés A. Vitamin D Treatment and Mortality in Chronic Kidney Disease: A Systematic Review and Meta-Analysis. Am J Nephrol. 2013;239–248. Doi: http://dx.doi.org/10.1159/000346846
12. Filho AJI, Melamed ML. Vitamin D andKidneyDisease. Whatweknowandwhatwe do notknowJ BrasNefrol. 2013;323-331. Doi: http://dx.doi.org/10.5935/0101-2800.20130051
13. Mann MC, Hoobs AJ, Hemmelgarn BR, Roberts DJ, Ahmed SB, Rabi DM. Effect of oral vitamin D analogs on mortality and cardiovascular outcomes among adults with chronic kidney disease: a meta-analysis. ClinKidney J. 2014;41–48. Doi: http://dx.doi.org/10.1093/ckj/sfu122
14. Parikh C, Gutgarts V, Eisenberg E, Melamed ML. Vitamin D and Clinical Outcomes in Dialysis. Semin Dial. 2014; 28(6):604–609. Doi:http://dx.doi.org/10.1111/sdi.12446
15. Ferreira A, Aires I, Nolasco F, Machado D, Macário F, Neves PL, et al. Benefits of selective vitamin D receptor activators in kidney transplanted patients. Port J NephrolHypert. 2015; 29(3):194-206. Disponível em: http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S087201692015000300003&lng=en.
16. Sekercioglu N, Busse JW, Sekercioglu MF, Agarwal A, Shaikh S, Lopes LC, et al. Cinacalcet versus standard treatment for chronic kidney disease: a systematic review and metaanalysis. RenFail. 2016; 38(6):857–874. Doi: http://dx.doi.org/10.3109/ 0886022X.2016.1172468
17. Magalhães LP, Reis LMD, Graciolli FG, Pereira BJ, Oliveira RBD, Souza AALD, et al. Predictive Factors of One-Year Mortality in a Cohort of Patients Undergoing Urgent-Start Hemodialysis. PloSOne. 2017; 1(3):1-8. Disponível em: https://observatorio.fm.usp.br/handle/OPI/18996
18. Hou YC, Liu WC, Zheng CM, Yen TH, Lu KC. Role of Vitamin D in Uremic Vascular Calcification. BioMedRes.Int. 2017; 1-11. DOI: https://doi.org/10.1155/2017/2803579
19. Shardlow A, Mclntyre NJ, Fluck RJ, Mclntyre CW, Taal MW. Associations of fibroblast growth factor 23, vitamin D and parathyroid hormone with 5 year outcomes in a prospective primary care cohort of people with chronic kidney disease stage 3. BMJ Open. 2017; 28(4): 83-92. Doi: http://dx.doi.org/10.1136/bmjopen-2017-016528
20. Hamano T. Vitamin D and renal outcome: the fourth outcome of CKD-MBD? Oshima AwardAddress 2015. J ClinExpNephrol .2018; 22(3): 249-256. Doi: http://dx.doi.org/10.1007/s10157-017-1517-3
21. Brzozka AG, Franzyck B, Ryzs AC, Olszewski R, Ryzs J. Impact of Vitamin D on the Cardiovascular System in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients. Nutrients. 2018;10(4):709-718. Doi:http://dx.doi.org/10.3390/nu10060709
22. Chen X, Lu YP, Luo T, Wu HW, Cai SF, Tian M, et al. Free 25-Vitamin D Is Correlated with Cardiovascular Events in Prevalent Hemodialysis Patients but Not with Markers of Renal Mineral Bone Disease. KidneyBlood Press Res. 2019;44(2):344-353.Doi:http://dx.doi.org/10.1159/000499878
23. Junarta J, Vivekanad JHA, Banerjee D. Insight into the impact of vitamin D on cardiovascular outcomes in chronic kidney disease. Nephrology. 2019; 24:781-90. Doi:https://doi.org/10.1111/nep.13569
24. Jean G, Souberbielle JC, Chazot C. Vitamin D in Chronic Kidney Disease and Dialysis Patients. Nutrients. 2017; 9(4) Doi:https://doi.org/10.3390/nu9040328
25. Kidney Disease: Improving Global Outcomes (KDIGO). KDIGO clinical practice guidelines for the diagnosis, evaluation, prevention and treatment of chronic kidney diseasemineral and bone disorder (CKD-MBD). KidneyIntSuppl. 2017;7:1-59
26. Matsumoto AK, Maes M, Michelin AP, Soares AE, Semeão LO, Godeny P, et al. Vitamin D deficiency is not associated with increased oxidative stress in chronic kidney disease pre-dialysis patients. Braz J Nephrol. 2020;42(4):420-8 Doi: https://doi.org/10.1590/2175-8239-jbn-2019-0156
27. Liu WC, Zheng CM, Lu CL et al: Vitamin D and immune function in chronic kidney disease. ClinChim Acta. 2015; 450:135-44. Doi: https://doi.org/10.1016/j.cca.2015.08.011
28. Jorge AJL, Cordeiro JR, Rosa MLG, Bianchi DBC. Deficiência da Vitamina D e Doenças Cardiovasculares Int J Cardiovasc Sci.2018; [online].aheadprint, PP.0-0 Doi:https://doi.org/10.5935/2359-4802.20180025
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Publicado
2021-03-22
Número
Sección
Artigos de revisão
Cómo citar
Deficiencia de vitamina D y mortalidad cardiovascular en la enfermedad renal crónica: revisión integradora. (2021). Ciência, Cuidado E Saúde, 20. https://doi.org/10.4025/ciencuidsaude.v20i0.50127
