Characterization of COVID-19 cases in critically ill patients: scoping review

Keywords: Coronavirus infections. COVID-19. Clinical manifestations. Critical care. Intensive care units.

Abstract

Introduction: The leading cause of mortality from the new coronavirus is respiratory failure. Accordingly, intensive care must be promptly provided to the critically ill patient. Objective: To explore the evidence about the clinical findings, treatment and outcome of Sars-CoV-2 infected patients admitted to Intensive Care Units. Method: Scoping review, carried out in April 2021, in eight national and international data sources, according to the guidelines of the Joanna Briggs Institute, following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews checklist, without language or time restrictions. The Population, Concept and Context strategy was adopted for the development of the research question. Results: A total of 15 scientific articles were included, with a predominance of publications in China, the United States of America and Canada. Of the studies, 80% were with adults and elderly in Intensive Care Unit. The main clinical findings were fever, cough, Acute Respiratory Distress Syndrome and kidney injury, treatment with invasive and non-invasive mechanical ventilation, high flow oxygen therapy and corticosteroids. The main outcome was death. Conclusion: Most patients presented with fever, cough and Acute Respiratory Distress Syndrome, receiving care such as mechanical ventilation, high flow oxygen therapy and corticosteroids, with a high death rate.

Downloads

Download data is not yet available.

Author Biographies

Thatiane Monick de Souza Costa, Federal University of Rio Grande do Norte

Enfermeira. Especialista. Aluna do curso de mestrado em Enfermagem na Universidade Federal do Rio Grande do Norte (UFRN). 

 

 

 

Kauanny Vitoria Gurgel dos Santos, Federal University of Rio Grande do Norte

Estudante. Graduanda de Enfermagem na UFRN. Bolsista de iniciação científica pelo Núcleo de Estudos e Pesquisas em Urgências, Emergência e Terapia Intensiva – NEPET.

Eloysa dos Santos Oliveira, Federal University of Rio Grande do Norte

Estudante. Graduanda de Enfermagem na UFRN. Bolsista de iniciação científica pelo Núcleo de Estudos e Pesquisas em Urgências, Emergência e Terapia Intensiva – NEPET.

Bruna Vilar Soares da Silva, Federal University of Rio Grande do Norte

Estudante. Graduanda de Enfermagem na UFRN. Bolsista de iniciação científica pelo Núcleo de Estudos e Pesquisas em Urgências, Emergência e Terapia Intensiva – NEPET.

Evelin Beatriz Bezerra de Melo, Federal University of Rio Grande do Norte

Estudante. Graduanda de Enfermagem na UFRN. Bolsista de iniciação científica pelo Núcleo de Estudos e Pesquisas em Urgências, Emergência e Terapia Intensiva – NEPET.

Rodrigo Assis Neves Dantas, Federal University of Rio Grande do Norte

Enfermeiro. Doutor. Professor adjunto na UFRN. Líder do Núcleo de Estudos e Pesquisas em Urgências, Emergência e Terapia Intensiva - NEPET.

Daniele Vieria Dantas, Federal University of Rio Grande do Norte

Enfermeira. Doutora. Professora adjunta na UFRN. 

References

Brasil. Ministério da Saúde. Sobre a doença: o que é covid-19. [Internet]. 2020 [citado em 2020 nov 23]. Disponível em: https://coronavirus.saude.gov.br/sobre-a-doenca#o-que-e-covid.

World Health Organization. Painel do WHO Coronavirus Disease (COVID-19). [Internet]. 2020 [citado 2021 jan 25]. Disponívelem: https://covid19.who.int/.

Halaçli B, Kaya A, Topeli A. Critically ill COVID-19 patient. Turk J Med Sci. 2020; 50 (3): 585-591. Doi: https://doi.org/10.3906/sag-2004-122.

Vincent JL, Taccone FS. Understanding Pathways to Death in Patients with COVID- 19. Lancet Respir Med. 2020; 8 (5): 2019-2021. Doi:https://doi.org/10.1016/S2213-2600(20)30165-X.

Grasselli G, Pesenti A, Cecconi M. Critical care utilization for the COVID-19 outbreak in Lombardy, Italy: early experience and forecast during an emergency response. JAMA. 2020; 323 (16): 1545-1546. Doi: https://doi.org/10.1001/jama.2020.4031.

Peters MDJ, Godfrey C, McInerney P, Munn Z, Tricco AC, Khalil, H. Chapter 11: Scoping Reviews (2020 version). In: Aromataris E, Munn Z (Editors). Joanna Briggs InstituteReviewer's Manual, JBI, 2020 [citado em 2020 nov 23]. Disponível em: https://reviewersmanual.joannabriggs.org/.

Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Med Intern. 2018; 169(7): 467-473. Doi: https://doi.org/10.7326/M18-0850.

Arentz M, Yim E, Klaff L, Lokhandwala S, Riedo FX, Chong M, et al. Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State. JAMA. 2020; 323 (16):1612-1614.Doi: https://doi.org/10.1001/jama.2020.4326.

Derespina KR, Kaushik S, Plichta A, Nadkarni VM, Agus MSD, Medar SS, et al. Clinical Manifestations and Outcomes of Critically Ill Children and Adolescents with Coronavirus Disease 2019 in New York City. J Pediatr. 2020; 226: 55-63. Doi: https://doi.org/10.1016/j.jpeds.2020.07.039.

Kayina CA, Haritha D, Soni L, Behera S, Nair PR, Gouri M, et al. Epidemiological & clinical characteristics & early outcome of COVID-19 patients in a tertiary care teaching hospital in India: A preliminary analysis. Indian J Med Res. 2020; 15 (1): 100-104. Doi: https://doi.org/10.4103/ijmr.IJMR_2890_20.

Xu J, Yang X, Yang L, Zou X, Wang Y, Wu Y, et al. Clinical course and predictors of 60-day mortality in 239 critically ill patients with COVID-19: a multicenter retrospective study from Wuhan, China. Crit Care. 2020; 24 (394): 5-11. Doi: https://doi.org/10.1186/s13054-020-03098-9.

Shekerdemian LS, Mahmood NR, Wolfe KK, Riggs BJ, Ross CE, McKiernan CA, et al. Characteristics and Outcomes of Children With Coronavirus Disease 2019 (COVID-19) Infection Admitted to US and Canadian Pediatric Intensive Care Units. JAMA Pediatr. 2020; 174 (9): 868-873. Doi: https://doi.org/10.1001/jamapediatrics.2020.1948.

Xie J, Wu W, Li S, Hu Y, Hu M, Li J, et al. Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study. Intensive Care Med. 2020; 46: 1863-1872. Doi: https://doi.org/10.1007/s00134-020-06211-2.

Wang ZH, Shu C, Ran X, Xie CH, Zhang L. Critically Ill Patients with Coronavirus Disease 2019 in a Designated ICU: Clinical Features and Predictors for Mortality. Risk ManagHealthc Policy. 2020; 13: 833-845. Doi: https://doi.org/10.2147/RMHP.S263095.

Mitra AR, Fergusson NA, Lioyd-Smith E, Wormsbecker A, Foster D, Karpov A, et al. Baseline characteristics and outcomes of patients with COVID-19 admitted to intensive care units in Vancouver, Canada: a case series. CMAJ. 2020; 192 (26): E694-E701. Doi: https://doi.org/10.1503/cmaj.200794.

Ñamendys-Silva AS, Alvarado-Ávila PE, Domínguez-Cherit G, Rivero-Sigarroa E, Sánchez-Hurtado LA, Gutiérrez-Villaseñor A, et al. Outcomes of patients with COVID-19 in the intensive care unit in Mexico: A multicenter observational study. Heart Lung. 2020; 50(1): 28-32. Doi: https://doi.org/10.1016/j.hrtlng.2020.10.013.

Yang X, Yu Y, Xu J, Shu H, Xie J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020; 8 (5): 475-481. Doi: https://doi.org/10.1016/S2213-2600(20)30079-5.

Shi M, Chen L, Yang Y, Zhang J, Xu J, Xu G, et al. Analysis of clinical features and outcomes of 161 patients with severe and critical COVID-19: A multicenter descriptive study. J Clin Lab Anal. 2020; 34 (9): 3-7. Doi: https://doi.org/10.1002/jcla.23415.

Yu Y, Xu D, Fu S, Zhang J, Yang X, Xu L. Patients with COVID-19 in 19 ICUs in Wuhan, China: a cross-sectional study. CritCare. 2020; 24 (219): 2-10. Doi: https://doi.org/10.1186/s13054-020-02939-x.

García-Salido A, Leoz-Gordillo I, Azagra-Garde AM, Nieto-Moro M, Iglesias-Bouzas MI, García-Teresa A, et al. Children in Critical Care Due to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Experience in a Spanish Hospital. PediatriCritCare Med. 2020; 21 (8): e576-e580. Doi: https://doi.org/10.1097/PCC.0000000000002475.

Xu Y, Xu Z, Liu X, Cai L, Zheng H, Huang Y, et al. Clinical Findings of COVID-19 Patients Admitted to Intensive Care Units in Guangdong Province, China: A Multicenter, Retrospective, Observational Study. Front Med. 2020; 7: 1-9. Doi: https://doi.org/10.3389/fmed.2020.576457.

Zhou Y, Han T, Chen J, Hou C, Hua L, He S, et al. Clinical and Autoimmune Characteristics of Severe and Critical Cases of COVID-19. Clin Transl Sci. 2020; 13 (6): 1077–1086. Doi: https://doi.org/10.1111/cts.12805.

Ayed M, Borahmah AA, Yazdani A, Sultão A, Mossad A, Rawdhan H. Assessment of Clinical Characteristics and Mortality-Associated Factors in COVID-19 Critical Cases in Kuwait. Med PrincPract. 2021; 30: 185-192. Doi: https://doi.org/10.1159/000513047

Sulaimana KAA, Aljuhanib O, Eljaalyb K, Alharbic AA, Shabasyd AMA, Alsaeedie AS, et al. Clinical features and outcomes of critically ill patients with coronavirus disease 2019 (COVID-19): A multicenter cohort study. Int J Infect Dis. 2021; 105: 180–187. Doi: https://doi.org/10.1016/j.ijid.2021.02.037.

Ahmed T, Shah RJ, Rahim SEG, Flores M, O’Linn A. Coronavirus Disease 2019 (COVID-19) Complicated by Acute Respiratory Distress Syndrome: An Internist’s Perspective. Cureus. 2020; 12 (3): e7482. Doi: https://doi.org/10.7759/cureus.7482.

Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020; 323 (13): 1239–1242. Doi: https://doi.org/10.1001/jama.2020.2648.

Fan H, Zhang L, Huang B, Zhu M, Zhou Y, Zhang H, et al. Cardiac injuries in patients with coronavirus disease 2019: Not to be ignored. Int J Infect Dis. 2020; 96: 294-297. Doi: https://doi.org/10.1016/j.ijid.2020.05.024.

Zhang D, Zhou X, Yan S, Tian R, Su L, Ding X, et al. Correlation between cytokines and coagulation-related parameters in patients with coronavirus disease 2019 admitted to ICU. Clin Chim Acta. 2020; 510: 47-53. Doi: https://doi.org/10.1016/j.cca.2020.07.002.

Hu Q, Guan H, Sun Z, Huang L, Chen C, Ai T, et al. Early CT features and temporal lung changes in COVID-19 pneumonia in Wuhan, China. Eur J Radiol. 2020; 128: 109017. Doi: https://doi.org/10.1016/j.ejrad.2020.109017.

Quintella CM, Quintella HM, Palma GB, Silva SCR, Silva GHR. Coronavírus (SARS-COV-2) e COVID-19: mapeamento de testes clínicos. Cadernos de Prospecção. 2020; 13(2): 397-411. Doi: https://doi.org/10.9771/cp.v13i2%20COVID-19.36175.

Bezerra DRC, Paulino ET, Santo FHE, Magalhães RS, Silva VG. Uso das Práticas Integrativas e Complementares no período de isolamento social da COVID-19 no Brasil. Res Soc Dev. 2020; 9 (1): 1-24. Doi: https://doi.org/10.33448/rsd-v9i11.9718.

Pan A, Liu L, Wang C, Guo H, Hao X, Wang Q, et al. Association of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan, China. JAMA. 2020; 323 (19): 1915-1923. Doi: https://doi.org/10.1001/jama.2020.6130.

Published
2021-09-08
How to Cite
de Souza Costa, T. M., Gurgel dos Santos, K. V., dos Santos Oliveira, E., Vilar Soares da Silva, B., Bezerra de Melo, E. B., Assis Neves Dantas, R., & Vieria Dantas, D. (2021). Characterization of COVID-19 cases in critically ill patients: scoping review. Ciência, Cuidado E Saúde, 20. https://doi.org/10.4025/ciencuidsaude.v20i0.57572
Section
Review articles