Comparison of metabolic parameters in children and adolescents with and without insulin resistance

Abstract

The aim of the study wast o compare the behavior of metabolic parameters, blood pressure and obesity indicators in children and adolescents with and without insulin resistance. Sixty-one overweight children (6 to 18 years) who underwent anthropometric measurements of body mass (MC), height and waist circumference (WC), blood pressure (BP), bioimpedance (relative fat (%G) and absolute (GC)) and blood collection for determination of glucose, insulin and lipid profile (TG, CT, HDL-C, LDL-C). The IMC z-score was used to classify the nutritional status and the HOMA-RI index (> 2.5) for insulin resistance. Participants were divided into two groups, resistant (RI, n= 27) and non-insulin resistant (NRI, n= 33). Regardless of age, children and adolescents with excess weight and IR presented higher MC, CC, BMI, %G and GC (kg), TG and plasma insulin than NRI counterparts, which in turn had higher LDL-C. The groups did not differ for the nutritional status (IMC z-score); however, in the comparison between the undesired proportions of the metabolic components, only three presented alterations with significant differences between the groups (TC, LDL-C and TG). It is concluded that IR is an influence for the development of dyslipidemias in this age group, especially TG.