Influence of vasoconstrictors associated with local anesthetics on the arterial pressure of hypertensive and normotensive rats

Abstract

The utilization of local anesthetics associated with vasoconstrictors in hypertensive patients is controversial. The purpose of this investigation was to verify the influence of this association on the arterial pressure (AP) in DOCA-salt hypertensive rats. After light ether anesthesia, the anesthetics (Group I - lidocaine 2% without vasoconstrictor; Group II - lidocaine 2% with phenylephrine, Group III - lidocaine 2% with noradrenaline- Group IV - prylocaine 3% with felypressin; Group V - mepivacaine 2% with epinephrine, and Group VI - mepivacaine 2% with norepinephrine) were injected into mucobuccal fold (infiltration anesthesia), in DOCA-salt and controls rats. The AP (by tail cuff method) was determined 5 and 15 minutes after the first dose of the anesthetic and also 5 and 15 minutes after the second dose. The data obtained indicated that the AP of DOCA-salt rats (193,05 ± 4,25mmHg; n = 43) was significantly increased when compared with controls (115,64 ± 2,47mmHg; n = 43) and b) there was no significant difference in the AP observed between DOCA-salt and control rats after administration of the local anesthetics tested. The data suggest that the presence of the vasoconstrictor agent associated with lidocaine 2%, prylocaine 3% and mepivacaine 2% did not interfere in the A. P. of these animals, in this experimental model of hypertension.