BASIDIOMYCOTA MUSHROOMS: SOURCES OF COMPOUNDS WITH ANTICANCER ACTIVITY
Keywords:
Beta-glucan, Secondary metabolites, Antitumor
Abstract
Wild mushrooms are fascinating for forming their fruiting bodies and their application in the food and medicine industry, presenting themselves as a great source of extraction of secondary metabolites with pharmacological properties. This review aims to provide information on the production of compounds with anticancer activity by mushrooms of the phylum Basidiomycota, presenting different molecules obtained from these organisms and how they act in the fight against tumor cells. Among the main drugs produced from these fungi, those used for cancer treatment stand out. The main primary metabolites extracted from this group and applied in pharmacological activities are the polysaccharides of the beta-glucan family. These compounds are found in the walls of fungi, which can act in the treatment of antitumor activities, as it stimulates the functioning of the immune system by increasing the blockade of cellular immunity.Downloads
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References
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ALONSO, E. N. et al. Antitumoral effects of D-fraction from Grifola frondosa (maitake) mushroom in breast cancer. Nutrition and cancer, v. 69, n. 1, p. 29-43, 2017.
BARBIERI, A. et al. Anticancer and anti-inflammatory properties of Ganoderma lucidum extract effects on melanoma and triple-negative breast cancer treatment. Nutrients, v. 9, n. 3, p. 210, 2017.
BELIZÁRIO, J. E. O próximo desafio, reverter o câncer. Ciência Hoje, v. 31, n. 184, p. 51-57, 2002.
BERTOLLO, A. G. et al. Agaricus blazei Murrill Mushroom: A Review on the Prevention and Treatment of Cancer. Pharmacological Research-Modern Chinese Medicine, p. 100032, 2021.
BLACKWELL, M. The Fungi: 1, 2, 3… 5.1 million species? American Journal of Botany, v. 98, n. 3, p. 426-438, 2011.
BOUEROY, P. et al. Anticancer effects of aurisin A extracts from Neonothopanus nambi on human papillomavirus-infected cervical cancer cells. Agriculture and Natural Resources, v. 55, n. 4, p. 618–627, 2021..
BOVI, M. et al. Structure of a lectin with antitumoral properties in king bolete (Boletus edulis) mushrooms. Glycobiology, v. 21, n. 8, p. 1000-1009, 2011.
CHAN, G. C-F.; CHAN, W. K.; SZE, D. M-Y. The effects of β-glucan on human immune and cancer cells. Journal of hematology & oncology, v. 2, n. 1, p. 1-11, 2009.
CHATURVEDI, V. K. et al. Medicinal mushroom: boon for therapeutic applications. 3 Biotech, v. 8, n. 8, p. 1-20, 2018.
CHEUNG, P. C. K. The nutritional and health benefits of mushrooms. Nutrition Bulletin, v. 35, n. 4, p. 292-299, 2010.
CONTI, R.; GUIMARÃES, D.O.; PUPO, M. T. Aprendendo com as interações da natureza: microrganismos simbiontes como fontes de produtos naturais bioativos. Ciência e Cultura, v. 64, n. 3, pág. 43-47, 2012.
EL-DEEB, N. M. et al. Alginate/κ-carrageenan oral microcapsules loaded with Agaricus bisporus polysaccharides MH751906 for natural killer cells mediated colon cancer immunotherapy. International Journal of Biological Macromolecules, v. 205, p. 385-395, 2022.
FAN, M-J. et al. Crude extracts of Agaricus brasiliensis induce apoptosis in human oral cancer CAL 27 cells through a mitochondria-dependent pathway. In vivo, v. 25, n. 3, p. 355-366, 2011.
FANG, J. et al. Structure of a β-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1/Syk/NF-κB signaling. Glycoconjugate journal, v. 29, n. 5, p. 365-377, 2012.
FERREIRA, I. C.F.R. et al. Cogumelos silvestres Portugueses: valorização como alimentos funcionais e fonte de nutracêuticos. In: Forum CIMO Ciência e Desenvolvimento 2012, 20 e 21 de Novembro de 2012. CIMO, 2012.
FINIMUNDY, T. C. et al. Aqueous extracts of Lentinula edodes and Pleurotus sajor-caju exhibit high antioxidant capability and promising in vitro antitumor activity. Nutrition Research, v. 33, n. 1, p. 76-84, 2013.
FORTES, R. C.; NOVAES, M. R. C. G. Efeitos da suplementação dietética com cogumelos Agaricales e outros fungos medicinais na terapia contra o câncer. Revista Brasileira de Cancerologia, v. 52, n. 4, p. 363-371, 2006.
GOMES, D.C.V. TOXICOGENÉTICA E OS EFEITOS ANTITUMORAIS DE EXTRATOS OBTIDOS DO NEONOTHOPANUS GARDNERI: POTENCIAL BIOTECNOLOGICO E FARMACEUTICO. 2020. Tese de Doutorado .
HETLAND, G. et al. Effects of the medicinal mushroom Agaricus blazei Murill on immunity, infection and cancer. Scandinavian journal of immunology, v. 68, n. 4, p. 363-370, 2008.
HETLAND, G. et al. Antitumor, anti-inflammatory and antiallergic effects of Agaricus blazei mushroom extract and the related medicinal Basidiomycetes mushrooms, Hericium erinaceus and Grifola frondosa: A review of preclinical and clinical studies. Nutrients, v. 12, n. 5, p. 1339, 2020.
HOBBS, C. Medicinal mushrooms: an exploration of tradition, healing, and culture. Book Publishing Company, 2002.
HU, M. et al. Induction of apoptosis in HepG2 cells by polysaccharide MEP-II from the fermentation broth of Morchella esculenta. Biotechnology letters, v. 35, n. 1, p. 1-10, 2013.
IKEKAWA, T. et al. Antitumor activity of aqueous extracts of edible mushrooms. Cancer research, v. 29, n. 3, p. 734-735, 1969.
JEDINAK, A. et al. Pleurotus ostreatus inhibits colitis-related colon carcinogenesis in mice. International journal of molecular medicine, v. 26, n. 5, p. 643-650, 2010.
JEONG, S. C. et al. Macrophage immunomodulating and antitumor activities of polysaccharides isolated from Agaricus bisporus white button mushrooms. Journal of medicinal food, v. 15, n. 1, p. 58-65, 2012.
KODAMA, N.; KOMUTA, K.; NANBA, H. Can maitake MD-fraction aid cancer patients? Alternative Medicine Review, v. 7, n. 3, p. 236-239, 2002.
KODAMA, N. et al. Potential antitumor activity of a low-molecular-weight protein fraction from Grifola frondosa through enhancement of cytokine production. Journal of medicinal food, v. 13, n. 1, p. 20-30, 2010.
LEE, S. R. et al. Bioactivity-guided isolation and chemical characterization of antiproliferative constituents from morel mushroom (Morchella esculenta) in human lung adenocarcinoma cells. Journal of Functional Foods, v. 40, p. 249-260, 2018.
LI, S. et al. Purification, antitumor and immunomodulatory activity of polysaccharides from soybean residue fermented with Morchella esculenta. International journal of biological macromolecules, v. 96, p. 26-34, 2017.
MAO, G-H. et al. Antitumor and immunomodulatory activity of a water-soluble polysaccharide from Grifola frondosa. Carbohydrate polymers, v. 134, p. 406-412, 2015.
MANCINA, E. G. Investigação da selectividad anticancerosa de nuevos compuestos y estrategias contra el câncer. 2021. Tese de Doutorado. Universidade de Sevilha, Sevilha, 2021.
MARTÍNEZ-MONTEMAYOR, M. M. et al. Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer. Nutrition and cancer, v. 63, n. 7, p. 1085-1094, 2011.
MASUDA, Yuki et al. Oral administration of soluble β‐glucans extracted from Grifola frondosa induces systemic antitumor immune response and decreases immunosuppression in tumor‐bearing mice. International Journal of Cancer, v. 133, n. 1, p. 108-119, 2013.
MOHARIB, Sorial A. et al. Anticancer activities of mushroom polysaccharides on chemically-induced colorectal cancer in rats. 2014.
PAULIUC, I. et al. Antitumor activity of Pleurotus ostreatus gemmotherapic extract. Annals of the Romanian Society for Cell Biology, v. 18, n. 1, p. 178, 2013.
PINTO, S. et al. Chemical characterization and antioxidant properties of Lepista nuda fruiting bodies and mycelia obtained by in vitro culture: Effects of collection habitat and culture media. Food research international, v. 51, n. 2, p. 496-502, 2013.
QU, L. et al. Anticancer effect of triterpenes from Ganoderma lucidum in human prostate cancer cells. Oncology letters, v. 14, n. 6, p. 7467-7472, 2017.
QUEIROZ, B. C. S. H. COMPOSIÇÃO FITOQUÍMICA E ATIVIDADES ANTILEISHMANIA, CITOTÓXICA, IMUNOMODULADORA E GENOTÓXICA DE NEONOTHOPANUS GARDNERI: UM COGUMELO BIOLUMINESCENTE. 2020.
REIS, F. S. et al. Leccinum vulpinum Watling induces DNA damage, decreases cell proliferation and induces apoptosis on the human MCF-7 breast cancer cell line. Food and Chemical Toxicology, v. 90, p. 45-54, 2016.
RESHETNIKOV, S. V.; TAN, K-K. Higher Basidiomycota as a source of antitumor and immunostimulating polysaccharides. International Journal of Medicinal Mushrooms, v. 3, n. 4, 2001.
RONY, K. A. et al. Ganoderma lucidum (Fr.) P. Karst occurring in South India attenuates gastric ulceration in rats. 2011.
ROSSI, P. et al. B-glucans from Grifola frondosa and Ganoderma lucidum in breast cancer: an example of complementary and integrative medicine. Oncotarget, v. 9, n. 37, p. 24837, 2018.
RUBEL, R. et al. Immunomodulatory and antitumoral properties of Ganoderma lucidum and Agaricus brasiliensis (Agaricomycetes) medicinal mushrooms. International journal of medicinal mushrooms, v. 20, n. 4, 2018.
RUTCKEVISKI, R. et al. Agaricus bisporus β-(1→ 6)-d-glucan induces M1 phenotype on macrophages and increases sensitivity to doxorubicin of triple negative breast cancer cells. Carbohydrate Polymers, v. 278, p. 118917, 2022.
KOSANIĆ, M.; PETROVIĆ, N.; STANOJKOVIĆ, T. Bioactive properties of Clitocybe geotropa and Clitocybe nebularis. Journal of Food Measurement and Characterization, v. 14, n. 2, p. 1046-1053, 2020.
DA SILVA, C. J. A.; DO NASCIMENTO MALTA, D. J. A importância dos fungos na biotecnologia. Caderno de Graduação-Ciências Biológicas e da Saúde-UNIT-PERNAMBUCO, v. 2, n. 3, p. 49-49, 2016.
SHANG, D. et al. A novel polysaccharide from Se-enriched Ganoderma lucidum induces apoptosis of human breast cancer cells. Oncology Reports, v. 25, n. 1, p. 267-272, 2011.
STROBEL, G.; DAISY, B. Bioprospecting for microbial endophytes and their natural products. Microbiology and molecular biology reviews, v. 67, n. 4, p. 491-502, 2003.
TAGUCHI, T. et al. Clinical efficacy of lentinan on neoplastic diseases. In: Biological Response Modifiers in Human Oncology and Immunology. Springer, Boston, MA, 1983. p. 181-187.
THYAGARAJAN, A. et al. Triterpenes from Ganoderma lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK). Nutrition and cancer, v. 62, n. 5, p. 630-640, 2010.
URBEN, A. F. Produção de cogumelos por meio de tecnologia chinesa modificada. Brasília: Embrapa Recursos Genéticos e Desenvolvimento, 2004.
VAZ, J. A. et al. Wild mushrooms Clitocybe alexandri and Lepista inversa: in vitro antioxidant activity and growth inhibition of human tumour cell lines. Food and Chemical Toxicology, v. 48, n. 10, p. 2881-2884, 2010.
VAZ, J. A. et al. Suillus collinitus methanolic extract increases p53 expression and causes cell cycle arrest and apoptosis in a breast cancer cell line. Food Chemistry, v. 135, n. 2, p. 596-602, 2012.
WANG, D-D. et al. Polysaccharide isolated from Sarcodon aspratus induces RAW264. 7 activity via TLR4-mediated NF-κB and MAPK signaling pathways. International journal of biological macromolecules, v. 120, p. 1039-1047, 2018.
WANG, D-D. et al. A novel polysaccharide from the Sarcodon aspratus triggers apoptosis in Hela cells via induction of mitochondrial dysfunction. Food & Nutrition Research, v. 62, 2018.
WANG, T. et al. Total triterpenoids from Ganoderma Lucidum suppresses prostate cancer cell growth by inducing growth arrest and apoptosis. Journal of Huazhong University of Science and Technology [Medical Sciences], v. 35, n. 5, p. 736-741, 2015.
WANG, X. et al. Ganoderma lucidum put forth anti-tumor activity against PC-3 prostate cancer cells via inhibition of Jak-1/STAT-3 activity. Saudi Journal of Biological Sciences, v. 27, n. 10, p. 2632-2637, 2020.
WANG, X-M. et al. A mini-review of chemical composition and nutritional value of edible wild-grown mushroom from China. Food chemistry, v. 151, p. 279-285, 2014.
WANG, Z. et al. Antioxidant and anti-tumour activity of triterpenoid compounds isolated from Morchella mycelium. Archives of Microbiology, v. 202, n. 7, p. 1677-1685, 2020.
WU, M-F. et al. Effect of Agaricus blazei Murrill extract on HT-29 human colon cancer cells in SCID mice in vivo. In vivo, v. 25, n. 4, p. 673-677, 2011.
WU, K. et al. Effects of non-steroidal anti-inflammatory drug-activated gene-1 on Ganoderma lucidum polysaccharides-induced apoptosis of human prostate cancer PC-3 cells. International journal of oncology, v. 53, n. 6, p. 2356-2368, 2018.
XU, W.; HUANG, J. J-H; CHEUNG, P. K.. Extract of Pleurotus pulmonarius suppresses liver cancer development and progression through inhibition of VEGF-induced PI3K/AKT signaling pathway. PLoS One, v. 7, n. 3, p. e34406, 2012.
ZHANG, M. et al. Antitumor polysaccharides from mushrooms: a review on their isolation process, structural characteristics and antitumor activity. Trends in Food Science & Technology, v. 18, n. 1, p. 4-19, 2007.
ZHAO, H. et al. Spore powder of Ganoderma lucidum improves cancer-related fatigue in breast cancer patients undergoing endocrine therapy: a pilot clinical trial. Evidence-Based Complementary and Alternative Medicine, v. 2012.
ALONSO, E. N. et al. Antitumoral effects of D-fraction from Grifola frondosa (maitake) mushroom in breast cancer. Nutrition and cancer, v. 69, n. 1, p. 29-43, 2017.
BARBIERI, A. et al. Anticancer and anti-inflammatory properties of Ganoderma lucidum extract effects on melanoma and triple-negative breast cancer treatment. Nutrients, v. 9, n. 3, p. 210, 2017.
BELIZÁRIO, J. E. O próximo desafio, reverter o câncer. Ciência Hoje, v. 31, n. 184, p. 51-57, 2002.
BERTOLLO, A. G. et al. Agaricus blazei Murrill Mushroom: A Review on the Prevention and Treatment of Cancer. Pharmacological Research-Modern Chinese Medicine, p. 100032, 2021.
BLACKWELL, M. The Fungi: 1, 2, 3… 5.1 million species? American Journal of Botany, v. 98, n. 3, p. 426-438, 2011.
BOUEROY, P. et al. Anticancer effects of aurisin A extracts from Neonothopanus nambi on human papillomavirus-infected cervical cancer cells. Agriculture and Natural Resources, v. 55, n. 4, p. 618–627, 2021..
BOVI, M. et al. Structure of a lectin with antitumoral properties in king bolete (Boletus edulis) mushrooms. Glycobiology, v. 21, n. 8, p. 1000-1009, 2011.
CHAN, G. C-F.; CHAN, W. K.; SZE, D. M-Y. The effects of β-glucan on human immune and cancer cells. Journal of hematology & oncology, v. 2, n. 1, p. 1-11, 2009.
CHATURVEDI, V. K. et al. Medicinal mushroom: boon for therapeutic applications. 3 Biotech, v. 8, n. 8, p. 1-20, 2018.
CHEUNG, P. C. K. The nutritional and health benefits of mushrooms. Nutrition Bulletin, v. 35, n. 4, p. 292-299, 2010.
CONTI, R.; GUIMARÃES, D.O.; PUPO, M. T. Aprendendo com as interações da natureza: microrganismos simbiontes como fontes de produtos naturais bioativos. Ciência e Cultura, v. 64, n. 3, pág. 43-47, 2012.
EL-DEEB, N. M. et al. Alginate/κ-carrageenan oral microcapsules loaded with Agaricus bisporus polysaccharides MH751906 for natural killer cells mediated colon cancer immunotherapy. International Journal of Biological Macromolecules, v. 205, p. 385-395, 2022.
FAN, M-J. et al. Crude extracts of Agaricus brasiliensis induce apoptosis in human oral cancer CAL 27 cells through a mitochondria-dependent pathway. In vivo, v. 25, n. 3, p. 355-366, 2011.
FANG, J. et al. Structure of a β-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1/Syk/NF-κB signaling. Glycoconjugate journal, v. 29, n. 5, p. 365-377, 2012.
FERREIRA, I. C.F.R. et al. Cogumelos silvestres Portugueses: valorização como alimentos funcionais e fonte de nutracêuticos. In: Forum CIMO Ciência e Desenvolvimento 2012, 20 e 21 de Novembro de 2012. CIMO, 2012.
FINIMUNDY, T. C. et al. Aqueous extracts of Lentinula edodes and Pleurotus sajor-caju exhibit high antioxidant capability and promising in vitro antitumor activity. Nutrition Research, v. 33, n. 1, p. 76-84, 2013.
FORTES, R. C.; NOVAES, M. R. C. G. Efeitos da suplementação dietética com cogumelos Agaricales e outros fungos medicinais na terapia contra o câncer. Revista Brasileira de Cancerologia, v. 52, n. 4, p. 363-371, 2006.
GOMES, D.C.V. TOXICOGENÉTICA E OS EFEITOS ANTITUMORAIS DE EXTRATOS OBTIDOS DO NEONOTHOPANUS GARDNERI: POTENCIAL BIOTECNOLOGICO E FARMACEUTICO. 2020. Tese de Doutorado .
HETLAND, G. et al. Effects of the medicinal mushroom Agaricus blazei Murill on immunity, infection and cancer. Scandinavian journal of immunology, v. 68, n. 4, p. 363-370, 2008.
HETLAND, G. et al. Antitumor, anti-inflammatory and antiallergic effects of Agaricus blazei mushroom extract and the related medicinal Basidiomycetes mushrooms, Hericium erinaceus and Grifola frondosa: A review of preclinical and clinical studies. Nutrients, v. 12, n. 5, p. 1339, 2020.
HOBBS, C. Medicinal mushrooms: an exploration of tradition, healing, and culture. Book Publishing Company, 2002.
HU, M. et al. Induction of apoptosis in HepG2 cells by polysaccharide MEP-II from the fermentation broth of Morchella esculenta. Biotechnology letters, v. 35, n. 1, p. 1-10, 2013.
IKEKAWA, T. et al. Antitumor activity of aqueous extracts of edible mushrooms. Cancer research, v. 29, n. 3, p. 734-735, 1969.
JEDINAK, A. et al. Pleurotus ostreatus inhibits colitis-related colon carcinogenesis in mice. International journal of molecular medicine, v. 26, n. 5, p. 643-650, 2010.
JEONG, S. C. et al. Macrophage immunomodulating and antitumor activities of polysaccharides isolated from Agaricus bisporus white button mushrooms. Journal of medicinal food, v. 15, n. 1, p. 58-65, 2012.
KODAMA, N.; KOMUTA, K.; NANBA, H. Can maitake MD-fraction aid cancer patients? Alternative Medicine Review, v. 7, n. 3, p. 236-239, 2002.
KODAMA, N. et al. Potential antitumor activity of a low-molecular-weight protein fraction from Grifola frondosa through enhancement of cytokine production. Journal of medicinal food, v. 13, n. 1, p. 20-30, 2010.
LEE, S. R. et al. Bioactivity-guided isolation and chemical characterization of antiproliferative constituents from morel mushroom (Morchella esculenta) in human lung adenocarcinoma cells. Journal of Functional Foods, v. 40, p. 249-260, 2018.
LI, S. et al. Purification, antitumor and immunomodulatory activity of polysaccharides from soybean residue fermented with Morchella esculenta. International journal of biological macromolecules, v. 96, p. 26-34, 2017.
MAO, G-H. et al. Antitumor and immunomodulatory activity of a water-soluble polysaccharide from Grifola frondosa. Carbohydrate polymers, v. 134, p. 406-412, 2015.
MANCINA, E. G. Investigação da selectividad anticancerosa de nuevos compuestos y estrategias contra el câncer. 2021. Tese de Doutorado. Universidade de Sevilha, Sevilha, 2021.
MARTÍNEZ-MONTEMAYOR, M. M. et al. Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer. Nutrition and cancer, v. 63, n. 7, p. 1085-1094, 2011.
MASUDA, Yuki et al. Oral administration of soluble β‐glucans extracted from Grifola frondosa induces systemic antitumor immune response and decreases immunosuppression in tumor‐bearing mice. International Journal of Cancer, v. 133, n. 1, p. 108-119, 2013.
MOHARIB, Sorial A. et al. Anticancer activities of mushroom polysaccharides on chemically-induced colorectal cancer in rats. 2014.
PAULIUC, I. et al. Antitumor activity of Pleurotus ostreatus gemmotherapic extract. Annals of the Romanian Society for Cell Biology, v. 18, n. 1, p. 178, 2013.
PINTO, S. et al. Chemical characterization and antioxidant properties of Lepista nuda fruiting bodies and mycelia obtained by in vitro culture: Effects of collection habitat and culture media. Food research international, v. 51, n. 2, p. 496-502, 2013.
QU, L. et al. Anticancer effect of triterpenes from Ganoderma lucidum in human prostate cancer cells. Oncology letters, v. 14, n. 6, p. 7467-7472, 2017.
QUEIROZ, B. C. S. H. COMPOSIÇÃO FITOQUÍMICA E ATIVIDADES ANTILEISHMANIA, CITOTÓXICA, IMUNOMODULADORA E GENOTÓXICA DE NEONOTHOPANUS GARDNERI: UM COGUMELO BIOLUMINESCENTE. 2020.
REIS, F. S. et al. Leccinum vulpinum Watling induces DNA damage, decreases cell proliferation and induces apoptosis on the human MCF-7 breast cancer cell line. Food and Chemical Toxicology, v. 90, p. 45-54, 2016.
RESHETNIKOV, S. V.; TAN, K-K. Higher Basidiomycota as a source of antitumor and immunostimulating polysaccharides. International Journal of Medicinal Mushrooms, v. 3, n. 4, 2001.
RONY, K. A. et al. Ganoderma lucidum (Fr.) P. Karst occurring in South India attenuates gastric ulceration in rats. 2011.
ROSSI, P. et al. B-glucans from Grifola frondosa and Ganoderma lucidum in breast cancer: an example of complementary and integrative medicine. Oncotarget, v. 9, n. 37, p. 24837, 2018.
RUBEL, R. et al. Immunomodulatory and antitumoral properties of Ganoderma lucidum and Agaricus brasiliensis (Agaricomycetes) medicinal mushrooms. International journal of medicinal mushrooms, v. 20, n. 4, 2018.
RUTCKEVISKI, R. et al. Agaricus bisporus β-(1→ 6)-d-glucan induces M1 phenotype on macrophages and increases sensitivity to doxorubicin of triple negative breast cancer cells. Carbohydrate Polymers, v. 278, p. 118917, 2022.
KOSANIĆ, M.; PETROVIĆ, N.; STANOJKOVIĆ, T. Bioactive properties of Clitocybe geotropa and Clitocybe nebularis. Journal of Food Measurement and Characterization, v. 14, n. 2, p. 1046-1053, 2020.
DA SILVA, C. J. A.; DO NASCIMENTO MALTA, D. J. A importância dos fungos na biotecnologia. Caderno de Graduação-Ciências Biológicas e da Saúde-UNIT-PERNAMBUCO, v. 2, n. 3, p. 49-49, 2016.
SHANG, D. et al. A novel polysaccharide from Se-enriched Ganoderma lucidum induces apoptosis of human breast cancer cells. Oncology Reports, v. 25, n. 1, p. 267-272, 2011.
STROBEL, G.; DAISY, B. Bioprospecting for microbial endophytes and their natural products. Microbiology and molecular biology reviews, v. 67, n. 4, p. 491-502, 2003.
TAGUCHI, T. et al. Clinical efficacy of lentinan on neoplastic diseases. In: Biological Response Modifiers in Human Oncology and Immunology. Springer, Boston, MA, 1983. p. 181-187.
THYAGARAJAN, A. et al. Triterpenes from Ganoderma lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK). Nutrition and cancer, v. 62, n. 5, p. 630-640, 2010.
URBEN, A. F. Produção de cogumelos por meio de tecnologia chinesa modificada. Brasília: Embrapa Recursos Genéticos e Desenvolvimento, 2004.
VAZ, J. A. et al. Wild mushrooms Clitocybe alexandri and Lepista inversa: in vitro antioxidant activity and growth inhibition of human tumour cell lines. Food and Chemical Toxicology, v. 48, n. 10, p. 2881-2884, 2010.
VAZ, J. A. et al. Suillus collinitus methanolic extract increases p53 expression and causes cell cycle arrest and apoptosis in a breast cancer cell line. Food Chemistry, v. 135, n. 2, p. 596-602, 2012.
WANG, D-D. et al. Polysaccharide isolated from Sarcodon aspratus induces RAW264. 7 activity via TLR4-mediated NF-κB and MAPK signaling pathways. International journal of biological macromolecules, v. 120, p. 1039-1047, 2018.
WANG, D-D. et al. A novel polysaccharide from the Sarcodon aspratus triggers apoptosis in Hela cells via induction of mitochondrial dysfunction. Food & Nutrition Research, v. 62, 2018.
WANG, T. et al. Total triterpenoids from Ganoderma Lucidum suppresses prostate cancer cell growth by inducing growth arrest and apoptosis. Journal of Huazhong University of Science and Technology [Medical Sciences], v. 35, n. 5, p. 736-741, 2015.
WANG, X. et al. Ganoderma lucidum put forth anti-tumor activity against PC-3 prostate cancer cells via inhibition of Jak-1/STAT-3 activity. Saudi Journal of Biological Sciences, v. 27, n. 10, p. 2632-2637, 2020.
WANG, X-M. et al. A mini-review of chemical composition and nutritional value of edible wild-grown mushroom from China. Food chemistry, v. 151, p. 279-285, 2014.
WANG, Z. et al. Antioxidant and anti-tumour activity of triterpenoid compounds isolated from Morchella mycelium. Archives of Microbiology, v. 202, n. 7, p. 1677-1685, 2020.
WU, M-F. et al. Effect of Agaricus blazei Murrill extract on HT-29 human colon cancer cells in SCID mice in vivo. In vivo, v. 25, n. 4, p. 673-677, 2011.
WU, K. et al. Effects of non-steroidal anti-inflammatory drug-activated gene-1 on Ganoderma lucidum polysaccharides-induced apoptosis of human prostate cancer PC-3 cells. International journal of oncology, v. 53, n. 6, p. 2356-2368, 2018.
XU, W.; HUANG, J. J-H; CHEUNG, P. K.. Extract of Pleurotus pulmonarius suppresses liver cancer development and progression through inhibition of VEGF-induced PI3K/AKT signaling pathway. PLoS One, v. 7, n. 3, p. e34406, 2012.
ZHANG, M. et al. Antitumor polysaccharides from mushrooms: a review on their isolation process, structural characteristics and antitumor activity. Trends in Food Science & Technology, v. 18, n. 1, p. 4-19, 2007.
ZHAO, H. et al. Spore powder of Ganoderma lucidum improves cancer-related fatigue in breast cancer patients undergoing endocrine therapy: a pilot clinical trial. Evidence-Based Complementary and Alternative Medicine, v. 2012.
Published
2022-08-22
How to Cite
1.
Bisanção VR, Polonio JC, Golias HC. BASIDIOMYCOTA MUSHROOMS: SOURCES OF COMPOUNDS WITH ANTICANCER ACTIVITY. arqmudi [Internet]. 2022Aug.22 [cited 2025Sep.6];26(2):29-6. Available from: https://periodicos.uem.br/ojs/index.php/ArqMudi/article/view/63571
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Section
Review article in Science, Biology and Biodiversity
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