Avaliação das atividades hipoglicemiante e anti-hiperglicemiante do extrato hidroalcóolico das folhas da Averrhoa carambola L. (Oxalidaceae) em modelos experimentais de hiperglicemia

Simone Tomás Gonçalves; Silmara Baroni; Fernando Antonio Bersani-Amado; Juliano Luiz Sartoretto; Diógenes Aparício Garcia Cortez; Carlos Alexandre Molena Fernandes; Ciomar Aparecida Bersani-Amado; Roberto Kenji Nakamura Cuman

doi:10.4025/actascihealthsci.v27i1.1443

Evaluation of hypoglycemic and antihyperglycemic activities in hydroethanolic extract of Averrhoa carambola L. (Oxalidaceae) in experimental models of hyperglycemia

Authors

Simone Tomás Gonçalves UEM Author
Silmara Baroni UEM Author
Fernando Antonio Bersani-Amado UEM Author
Juliano Luiz Sartoretto UEM Author
Diógenes Aparício Garcia Cortez UEM Author
Carlos Alexandre Molena Fernandes UEM Author
Ciomar Aparecida Bersani-Amado UEM Author
Roberto Kenji Nakamura Cuman Farmácia/Análises Clínicas - UEM Author

DOI:

https://doi.org/10.4025/actascihealthsci.v27i1.1443

Keywords:

Averrhoa carambola, hiperglicemia, produtos naturais

Abstract

The hypoglycemic and antihyperglycemic activities of a hydroethanolic extract prepared from the leaves of Averrhoa carambola L. (Oxalidaceae) was evaluated in rats, through the experimental models of hyperglycemia: type 1 alloxan-induced diabetes, glucose intolerance and insulin resistance induced by dexamethasone and the chronic insulin resistance in obesity model induced by sodium monoglutamate. The hydroethanolic Averrhoa carambola extract at a dosage of 800 mg/Kg body weight did not exhibit hypoglycemic and antihyperglycemic activities in the hyperglycemic experimental models tested

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Author Biography

Roberto Kenji Nakamura Cuman, Farmácia/Análises Clínicas - UEM

Possui graduação em Farmácia pela Universidade Federal do Rio Grande do Sul (1984), mestrado em Farmacologia pela Universidade de São Paulo (1993) e doutorado em Farmacologia pela Universidade de São Paulo (1998). Atualmente é Diretor Presidente da Fundação de Apoio Ao Desenvolvimento Científico da Universidade Estadual de e professor associado da Universidade Estadual de Maringá. Tem experiência na área de Farmacologia, com ênfase em Farmacologia Geral, atuando principalmente nos seguintes temas: diabetes tipo 2, inflamação, diabetes, farmacoepidemiologia e inflamacao. Currículo Lattes

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Published

2008-03-26

Issue

Vol. 27 No. 1 (2005)

Section

Pharmacy

License

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How to Cite

Gonçalves, S. T., Baroni, S., Bersani-Amado, F. A., Sartoretto, J. L., Cortez, D. A. G., Fernandes, C. A. M., Bersani-Amado, C. A., & Cuman, R. K. N. (2008). Evaluation of hypoglycemic and antihyperglycemic activities in hydroethanolic extract of Averrhoa carambola L. (Oxalidaceae) in experimental models of hyperglycemia. Acta Scientiarum. Health Sciences, 27(1), 49-55. https://doi.org/10.4025/actascihealthsci.v27i1.1443