Polimorfismo do gene ACTN3 e os fatores associados ao desempenho funcional de idosas atendidas na atenção primária em saúde

Leandro César Teixeira  Machado; Mateus Medeiros; Marina Morato Stival; Yuri Gustavo de Sousa Barbalho; Filipe Dinato de Lima; Luciano Ramos de Lima; Alessandro de Oliveira Silva; Izabel Cristina Rodrigues da Silva; Silvana Schwerz  Funghetto

doi:10.4025/jphyseduc.v33i1.3351

Leandro César Teixeira Machado University of Brasília (UnB), Brasília-DF, Brazil https://orcid.org/0000-0002-7003-6442
Mateus Medeiros University of Brasília (UnB), Brasília-DF, Brazil https://orcid.org/0000-0002-0438-3833
Marina Morato Stival University of Brasília (UnB), Brasília-DF, Brazil https://orcid.org/0000-0001-6830-4914
Yuri Gustavo de Sousa Barbalho University of Brasília (UnB), Brasília-DEF, Brazil
Filipe Dinato de Lima University Center of Brasília (UniCEUB), Brasília-DF, Brazil
Luciano Ramos de Lima University of Brasília (UnB), Brasília-DF, Brazil https://orcid.org/0000-0002-2709-6335
Alessandro de Oliveira Silva University Center of Brasília (UniCEUB), Brasília-DF, Brazil https://orcid.org/0000-0003-3513-7034
Izabel Cristina Rodrigues da Silva University of Brasília (UnB), Brasília-DF, Brazil https://orcid.org/0000-0002-6836-3583
Silvana Schwerz Funghetto University of Brasília (UnB), Brasília-DF, Brazil https://orcid.org/0000-0002-9332-9029

DOI: https://doi.org/10.4025/jphyseduc.v33i1.3351

Keywords: Functional performance, Genetic variation, Aging, Muscle strengh

Abstract

Objective: to analyze the potential influences of the R/X genetic polymorphism of the ACTN3 gene and of anthropometric and metabolic characteristics on the functional performance of elderly women assisted in primary health care. Method: One hundred and forty-one elderly women were evaluated in relation to anthropometric, metabolic, functional, clinical, cognitive and demographic characteristics. The frequencies of alleles and genotypes of the ACTN3 gene polymorphism were determined. Results: 141 elderly women (68.30 ± 6.18 years) were evaluated. There were no significant differences (p > 0.05) between the RR and RX/XX genotypes in the functional performance, anthropometric or metabolic characteristics of the elderly women. The duration of the TUG test showed positive correlations with age, body mass index, waist circumference and fat percentage (s = 0.315; p < 0.001; s = 0.238; p = 0.005; s = 0.174; p = 0.039; s = 0.207; p = 0.014) respectively. Negative correlations were observed between the TUG with absolute (s = - 0.314; p < 0.001) and relative (s = - 0.380; p < 0.001) handgrip strength. Conclusion: In our study, no influences of ACTN3 gene polymorphisms were observed on the functional performance of elderly women, which was influenced by other factors.